Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis
ATTRACT completes accrual of planned cohort
On behalf of its steering committee, Principal Investigator Suresh Vedantham is pleased to announce that the NIH-sponsored Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis (ATTRACT) Study has completed accrual of its originally planned cohort of 692 patients. ATTRACT, which enrolled patients in 56 hospitals, will determine if the use of pharmacomechanical catheter-directed thrombolysis in patients with acute proximal deep vein thrombosis (DVT) prevents the post-thrombotic syndrome and improves quality of life.
According to Dr. Vedantham, "ATTRACT is more than three times the size of the only other multicenter randomized controlled trial of DVT thrombolysis. Combined with its strong methodological design and rigorous conduct, the successful enrollment of the entire sample should cement the credibility of the study’s results. This could not have occurred without strong community participation, including our active collaboration with SIR Foundation and a public endorsement of the study by the U.S. surgeon general."
History of Attract
The Acute Venous Thrombosis: Thombus Removal with Adjunctive Catheter-directed Thrombolysis (ATTRACT) trial was designed in 2005, based on the outcome of an SIR Foundation research consensus panel that took place in October 2004. The SIR Foundation began working with Suresh Vedantham, M.D., from the Washington University School of Medicine in 2006 to develop the National Institutes of Health (NIH) R01 application for the ATTRACT trial.
ATTRACT is designed to evaluate the ability of catheter-directed thrombolysis to reduce the incidence and severity in patients with acute proximal deep vein thrombosis (DVT). ATTRACT was submitted to the NIH's National Heart, Lung and Blood Institute in 2006 and received $10.2 million in funding. SIR Foundation participates as a collaborating institution in the development and execution of the trial.